Protein Name:
GRIP1-associated protein 1
|
UniprotKB/SwissProt ID: Q4V328 (Q4V328)
Gene Name:
GRIPAP1
Organism: Homo sapiens (Human)
Function: Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity) Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome membrane. Recycling endosome membrane. Cell projection, axon. Cell projection, dendrite. Synapse
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q4V328
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
581 |
QLEQAQEERD C HLKTISSLKQ |
|
|
|
| 2 |
744 |
VSSASMAEDL C RKSAIIETYV |
|
|
|
| 3 |
827 |
SQEIVRLSKE C VGPPDPDLEP |
|
|
|
|
