UniprotKB/SwissProt ID: Q4JEI2 (Q4JEI2)
Gene Name:
Defal1
Organism: Rattus norvegicus (Rat)
Function: Intestinal defense peptide (PubMed:23380721, PubMed:28345637). Has potent antibacterial activity against Gram-negative bacteria E.coli O157:H7, S.typhimurium DT104, and K.pneumoniae; and against Gram-positive bacteria S.aureus, methicillin-resistant S.aureus and L.monocytogenes (PubMed:23380721, PubMed:28345637). Remains active in the presence of NaCl and Mg(2+) (PubMed:23380721). Probably functions by disrupting bacterial membrane integrity (PubMed:28345637). However, does not show cytotoxic activity towards human intestinal cells (PubMed:23380721)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
|
|
|
