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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Malonate--CoA ligase ACSF3, mitochondrial

UniprotKB/SwissProt ID: Q4G176 (Q4G176)

Gene Name: ACSF3

Organism: Homo sapiens (Human)

Function: Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester (PubMed:21841779, PubMed:21846720). May have some preference toward very-long-chain substrates (PubMed:17762044)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR025110 AMP-bd_C
IPR045851 AMP-bd_C_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_synth/lig_dom
IPR042099 ANL_N_sf

The S-nitrosylation sites of Q4G176

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 399 IVSENPQREA C SYTIHAEGDE