Protein Name:
Adrenocortical dysplasia protein homolog
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UniprotKB/SwissProt ID: Q4FZR5 (Q4FZR5)
Gene Name:
Acd
Organism: Rattus norvegicus (Rat)
Function: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome, telomere
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q4FZR5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
329 |
LRHAPTSYQA C ETRTQFHKLE |
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