Protein Name:
Leucine-rich repeat flightless-interacting protein 1
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UniprotKB/SwissProt ID: Q3UZ39 (Q3UZ39)
Gene Name:
Lrrfip1
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA (By similarity). Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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