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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: LIM and calponin homology domains-containing protein 1

UniprotKB/SwissProt ID: Q3UH68 (Q3UH68)

Gene Name: Limch1

Organism: Mus musculus (Mouse)

Function: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton, stress fiber

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001997 Calponin/LIMCH1
IPR001715 CH_dom
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR001781 Znf_LIM

The S-nitrosylation sites of Q3UH68

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 929 QLEAEAGAPH C GTNPQPAQDP  CCCCCCCCEE C CCCCCCCCCC  7.57% 21278135