UniprotKB/SwissProt ID: Q3UEN2 (Q3UEN2)
Gene Name:
Shld2
Organism: Mus musculus (Mouse)
Function: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Chromosome
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