Protein Name:
Alanine--glyoxylate aminotransferase 2, mitochondrial
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UniprotKB/SwissProt ID: Q3UEG6 (Q3UEG6)
Gene Name:
Agxt2
Organism: Mus musculus (Mouse)
Function: Multifunctional aminotransferase with a broad substrate specificity (PubMed:23023372, PubMed:23154179, PubMed:23280748, PubMed:27062388). Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (By similarity). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine (PubMed:27062388). Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate (PubMed:27062388). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) (PubMed:23023372, PubMed:23154179, PubMed:23280748). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (PubMed:23023372)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q3UEG6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
199 |
IISFRGAYHG C SPYTLGLTNV |
CCCCHHHCCC C CCHHHHHHHH |
2.06% |
22178444
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| 2 |
463 |
KTEVNQIHED C KDMGLLVGRG |
CCCCHHHCCC C CCHHHHHHHH |
3.52% |
22178444
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