Protein Name:
UMP-CMP kinase 2, mitochondrial
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UniprotKB/SwissProt ID: Q3U5Q7 (Q3U5Q7)
Gene Name:
Cmpk2
Organism: Mus musculus (Mouse)
Function: Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities (By similarity). Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity (By similarity). Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides (PubMed:36443312). CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators (PubMed:30046112). In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation (PubMed:30046112)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q3U5Q7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
243 |
ARAVLDLVDQ C PKEVQKGKFQ |
CCCCCCCCCC H HHHHHHHHHH |
4.5% |
20925432
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| 2 |
422 |
MTYQRMENPS C HLVDASPSRE |
CCCCCCCCCC H HHHHHHHHHH |
2.8% |
21278135
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| 3 |
44 |
PRRFTVELPD C SLTHFVLGDA |
CCCCCCCCCC H HHHHHHHHHH |
3.2% |
20925432
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