UniprotKB/SwissProt ID: Q3TQQ9 (Q3TQQ9)
Gene Name:
Firrm
Organism: Mus musculus (Mouse)
Function: Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities. Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis. In complex with FIGL1 may regulate homologous recombination
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Chromosome, centromere, kinetochore. Nucleus. Chromosome, centromere. Midbody. Cytoplasm, cytoskeleton, spindle
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