Protein Name:
Dimethyladenosine transferase 2, mitochondrial
|
UniprotKB/SwissProt ID: Q3TL26 (Q3TL26)
Gene Name:
Tfb2m
Organism: Mus musculus (Mouse)
Function: S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (By similarity). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:15526033). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:15526033). Stimulates transcription independently of the methyltransferase activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
