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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Rho GTPase-activating protein 45

UniprotKB/SwissProt ID: Q3TBD2 (Q3TBD2)

Gene Name: Arhgap45

Organism: Mus musculus (Mouse)

Function: Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell projection, ruffle membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR027267 AH/BAR_dom_sf
IPR046349 C1-like_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR054713 GMIP/FCHO2-like_FCH
IPR002219 PE/DAG-bd
IPR057028 RHG29_45_N
IPR008936 Rho_GTPase_activation_prot
IPR051025 RhoGAP
IPR000198 RhoGAP_dom

The S-nitrosylation sites of Q3TBD2

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 135 FAEGLEKLKE C VLQDDLLEAR   
2 277 PEEVDMLLQR C EGGVDAALQY   
3 736 EECCLACHKK C LETLAIQCGH