Protein Name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
|
UniprotKB/SwissProt ID: Q3LAC4 (Q3LAC4)
Gene Name:
Prex2
Organism: Mus musculus (Mouse)
Function: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
