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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Zeta-carotene desaturase, chloroplastic/chromoplastic

UniprotKB/SwissProt ID: Q38893 (Q38893)

Gene Name: ZDS1

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Plays a crucial role in plant growth and development. Is essential for the biosynthesis of carotenoids. Carotenoids are involved in different physiological processes, including coloration, photoprotection, biosynthesis of abscisic acid (ABA) and chloroplast biogenesis (PubMed:17468780, PubMed:24907342). Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'. Shows stereoselectivity toward trans C15-C15'zeta-carotene double bond. The zeta-carotene produced by the phytoene desaturase PDS has a C15-C15' double bond in the cis configuration and it requires isomerization before being recognized as substrate by ZDS. The main product is 7,9,7',9'-tetra-cis-lycopene (pro-lycopene) (PubMed:9914519)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Plastid, chloroplast. Plastid, chromoplast

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR014103 Zeta_caro_desat
IPR050464 Zeta_carotene_desat/Oxidored

The S-nitrosylation sites of Q38893

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 531 LSGRQASSYI C DAGEELAELN