Protein Name:
Leucine-rich repeat flightless-interacting protein 1
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UniprotKB/SwissProt ID: Q32MZ4 (Q32MZ4)
Gene Name:
LRRFIP1
Organism: Homo sapiens (Human)
Function: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q32MZ4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
14 |
PAAAQSREID C LSPEAQKLAE |
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| 2 |
334 |
EQHTEDTVKD C VDIEVFPAGE |
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| 3 |
456 |
SDDTVYHDDK C MVEVPQELET |
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| 4 |
529 |
PGSPAGTEGN C QEATGPSTVD |
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| 5 |
644 |
IAAESSENVD C PENPKIKLDG |
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| 6 |
726 |
AEPKSEDADR C TLPEHESPSQ |
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| 7 |
750 |
DACEAESTER C EMSEHPSQTV |
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