UniprotKB/SwissProt ID: Q32M21 (Q32M21)
Gene Name:
Gsdma2
Organism: Mus musculus (Mouse)
Function: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon bacterial infection, specifically cleaved by some bacterial effector protein, releasing the N-terminal moiety (Gasdermin-A2, N-terminal) that binds to membranes and forms pores, triggering pyroptosis Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage of Gasdermin-A2, and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, perinuclear region. Cytoplasm, cytosol. Cell membrane
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