UniprotKB/SwissProt ID: Q2VLH6 (Q2VLH6)
Gene Name:
Cd163
Organism: Mus musculus (Mouse)
Function: Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity) After shedding, the soluble form (sCD163) may play an anti-inflammatory role
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Cell membrane
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