UniprotKB/SwissProt ID: Q2EEY0 (Q2EEY0)
Gene Name:
TLR9
Organism: Equus caballus (Horse)
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cell membrane. Cytoplasm. Nucleus
|
|
|
