UniprotKB/SwissProt ID: Q28820 (Q28820)
Gene Name:
TRDN
Organism: Oryctolagus cuniculus (Rabbit)
Function: Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction (PubMed:17846166, PubMed:19398037, PubMed:7721813). Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Sarcoplasmic reticulum membrane
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