UniprotKB/SwissProt ID: Q1XA76 (Q1XA76)
Gene Name:
ASIC1
Organism: Gallus gallus (Chicken)
Function: Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:16002453, PubMed:17882215, PubMed:19641589, PubMed:24507937). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:22842900, PubMed:24507937). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:24507937). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Postsynaptic cell membrane. Cell projection, dendrite
|
|
|
