UniprotKB/SwissProt ID: Q19QX0 (Q19QX0)
Gene Name:
S
Organism: Severe acute respiratory syndrome coronavirus (SARS-CoV)
Function: Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Host cell membrane. Host endoplasmic reticulum-Golgi intermediate compartment membrane. Virion membrane
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