Protein Name:
Thioredoxin reductase 1, cytoplasmic
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UniprotKB/SwissProt ID: Q16881 (Q16881)
Gene Name:
TXNRD1
Organism: Homo sapiens (Human)
Function: Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437) Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2 Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm. Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q16881
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
209 |
LGTRWGLGGT C VNVGCIPKKL |
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| 2 |
214 |
GLGGTCVNVG C IPKKLMHQAA |
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| 3 |
327 |
YLGIPGDKEY C ISSDDLFSLP |
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| 4 |
339 |
SSDDLFSLPY C PGKTLVVGAS |
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| 5 |
515 |
QRLYAGSTVK C DYENVPTTVF |
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| 6 |
533 |
TVFTPLEYGA C GLSEEKAVEK |
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| 7 |
577 |
DNNKCYAKII C NTKDNERVVG |
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| 8 |
647 |
RSGASILQAG C UG-------- |
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