UniprotKB/SwissProt ID: Q16820 (Q16820)
Gene Name:
MEP1B
Organism: Homo sapiens (Human)
Function: Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Also cleaves the amyloid precursor protein/APP, thereby releasing neurotoxic amyloid beta peptides (PubMed:27180357)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Secreted
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