Protein Name:
Guanylate kinase
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UniprotKB/SwissProt ID: Q16774 (Q16774)
Gene Name:
GUK1
Organism: Homo sapiens (Human)
Function: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for converting prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Photoreceptor inner segment. Cytoplasm, cytosol. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q16774
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
98 |
VQAVQAMNRI C VLDVDLQGVR |
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