Protein Name:
Glutaminyl-peptide cyclotransferase
|
UniprotKB/SwissProt ID: Q16769 (Q16769)
Gene Name:
QPCT
Organism: Homo sapiens (Human)
Function: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
