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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Bcl-2 homologous antagonist/killer

UniprotKB/SwissProt ID: Q16611 (Q16611)

Gene Name: BAK1

Organism: Homo sapiens (Human)

Function: Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion outer membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR036834 Bcl-2-like_sf
IPR046371 Bcl-2_BH1-3
IPR026298 Bcl-2_fam
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR020728 Bcl2_BH3_motif_CS

The S-nitrosylation sites of Q16611

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 14 GQGPGPPRQE C GEPALPSASE