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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hsp90 co-chaperone Cdc37

UniprotKB/SwissProt ID: Q16543 (Q16543)

Gene Name: CDC37

Organism: Homo sapiens (Human)

Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR004918 Cdc37
IPR013873 Cdc37_C
IPR013874 Cdc37_Hsp90-bd
IPR038189 Cdc37_Hsp90-bd_sf
IPR013855 Cdc37_N_dom

The S-nitrosylation sites of Q16543

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 308 YESLPEELQK C FDVKDVQMLQ  CCCCCCCCCC C CCCCCCCCCC  1.96% 19483679
2 336 PTDAKYHMQR C IDSGLWVPNS  CCCCCCCCCC C CCCCCCCCCC  1.97% 19483679