Protein Name:
UDP-N-acetylhexosamine pyrophosphorylase
|
UniprotKB/SwissProt ID: Q16222 (Q16222)
Gene Name:
UAP1
Organism: Homo sapiens (Human)
Function: Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (PubMed:9765219). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (PubMed:36603579) Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P) Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q16222
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
293 |
TNPTEPVGVV C RVDGVYQVVE |
CCHHHHHHHH H HHHHHHHHHH |
3.05% |
2212679
|
| 2 |
481 |
LKDANDVPIQ C EISPLISYAG |
CCHHHHHHHH H HHHHHHHHHH |
5.33% |
|
|
