Protein Name:
Ras-related protein Rab-30
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UniprotKB/SwissProt ID: Q15771 (Q15771)
Gene Name:
RAB30
Organism: Homo sapiens (Human)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22188167). RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (PubMed:22188167). Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner (By similarity). Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection (PubMed:26771875)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus membrane. Cytoplasm. Cytoplasmic vesicle, autophagosome membrane. Autolysosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q15771
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
168 |
NVEKLFLDLA C RLISEARQNT |
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| 2 |
99 |
YDITCEESFR C LPEWLREIEQ |
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