Protein Name:
Scaffold attachment factor B1
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UniprotKB/SwissProt ID: Q15424 (Q15424)
Gene Name:
SAFB
Organism: Homo sapiens (Human)
Function: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q15424
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
225 |
EKILDILGET C KSEPVKEESS |
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| 2 |
362 |
EDGRKFDFDA C NEVPPAPKES |
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| 3 |
448 |
VTNARSPGAR C YGFVTMSTAE |
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