Protein Name:
Delta(24)-sterol reductase
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UniprotKB/SwissProt ID: Q15392 (Q15392)
Gene Name:
DHCR24
Organism: Homo sapiens (Human)
Function: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:22178193, PubMed:25637936). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Golgi apparatus membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q15392
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
252 |
FEPVRGLEAI C AKFTHESQRQ |
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| 2 |
499 |
LYHKLREKLG C QDAFPEVYDK |
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