Protein Name:
Zinc finger MYND domain-containing protein 11
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UniprotKB/SwissProt ID: Q15326 (Q15326)
Gene Name:
ZMYND11
Organism: Homo sapiens (Human)
Function: Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q15326
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
142 |
RLRDSSSPWQ C PVCRSIKKKN |
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