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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Rab GTPase-binding effector protein 1

UniprotKB/SwissProt ID: Q15276 (Q15276)

Gene Name: RABEP1

Organism: Homo sapiens (Human)

Function: Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR003914 Rabaptin
IPR018514 Rabaptin_coiled-coil
IPR015390 Rabaptin_Rab5-bd_dom

The S-nitrosylation sites of Q15276

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 263 EKLRKELHEV C HLLEQERQQH   
2 350 VEEEIKIPVV C ALTQEESSAQ   
3 718 FLKEQIQAEQ C LKENLEETLQ   
4 734 EETLQLEIEN C KEEIASISSL