Protein Name:
Prostaglandin E synthase 3
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UniprotKB/SwissProt ID: Q15185 (Q15185)
Gene Name:
PTGES3
Organism: Homo sapiens (Human)
Function: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q15185
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
20 |
DRRDYVFIEF C VEDSKDVNVN |
CCCCCCCCCC C CCEEEEEEEE |
1.81% |
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| 2 |
40 |
NFEKSKLTFS C LGGSDNFKHL |
CCCCCCCCCC C CCEEEEEEEE |
3.41% |
19483679
|
| 3 |
58 |
KHLNEIDLFH C IDPNDSKHKR |
CCCCCCCCCC C CCEEEEEEEE |
2.71% |
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| 4 |
75 |
KHKRTDRSIL C CLRKGESGQS |
CCCCCCCCCC C CCEEEEEEEE |
1.64% |
19483679
|
| 5 |
76 |
HKRTDRSILC C LRKGESGQSW |
CCCCCCCCCC C CCEEEEEEEE |
3.55% |
19483679
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