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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Plectin
UniprotKB/SwissProt ID: Q15149 (Q15149)

Gene Name: PLEC

Organism: Homo sapiens (Human)

Function: Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell junction, hemidesmosome. Cell projection, podosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001589 Actinin_actin-bd_CS
IPR001715 CH_dom
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR049538 PCN-like_spectrin-like_rpt
IPR043197 Plakin
IPR035915 Plakin_repeat_sf
IPR005326 Plectin_eS10_N
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR036388 WH-like_DNA-bd_sf
The S-nitrosylation sites of Q15149
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1098 RLMAEREYGS C SHHYQQLLQS  CCCCCCCCHH H HHHHHHHHHH  3.79% 20140087
2 1136 LKDIRLQLEA C ETRTVHRLRL  CCCCCCCCHH H HHHHHHHHHH  3.91% 20140087
3 3017 RCVEDPETGL C LLPLTDKAAK  CCCCCCCCHH H HHHHHHHHHH  3.77%
4 3110 VEEQEQKGRL C FEGLRSLVPA  CCCCCCCCHH H HHHHHHHHHH  2.55%
5 317 RMVEGYQGLR C DNFTSSWRDG  CCCCCCCCHH H HHHHHHHHHH  6.36%
6 3295 KSHRVPLDVA C ARGCLDEETS  CCCCCCCCHH H HHHHHHHHHH  2.39% 20140087
2212679
7 3299 VPLDVACARG C LDEETSRALS  CCCCCCCCHH H HHHHHHHHHH  3.45% 20140087
8 3336 PATYGELQQR C RPDQLTGLSL  CCCCCCCCHH H HHHHHHHHHH  6.86% 20140087
37478858
9 3493 SVRTLLQGSG C LAGIYLEDTK  CCCCCCCCHH H HHHHHHHHHH  2.23%
10 3667 NLTYRQLLER C VEDPETGLRL  CCCCCCCCHH H HHHHHHHHHH  2.61% 20140087
11 3821 REALEAESAW C YLYGTGSVAG  CCCCCCCCHH H HHHHHHHHHH  1.35%
12 4071 NLQKFLEGTS C IAGVFVDATK  CCCCCCCCHH H HHHHHHHHHH  2.19%
13 4245 NLTYLQLMER C ITDPQTGLCL  CCCCCCCCHH H HHHHHHHHHH  2.21%
14 4454 TGQRLLEAQA C TGGIIDPSTG  CCCCCCCCHH H HHHHHHHHHH  2.12%
15 4574 DVGAYSKYLT C PKTKLKISYK  CCCCCCCCHH H HHHHHHHHHH  2.76%
16 545 VTKLQMEAGL C EEQLNQADAL  CCCCCCCCHH H HHHHHHHHHH  5.45%
17 950 MRGRLPLLAV C DYKQVEVTVH  CCCCCCCCHH H HHHHHHHHHH  3.83% 20140087
18 965 VEVTVHKGDE C QLVGPAQPSH  CCCCCCCCHH H HHHHHHHHHH  4.51%
19 992 SGSEAAVPSV C FLVPPPNQEA  CCCCCCCCHH H HHHHHHHHHH  2.27%