Protein Name:
Peroxisomal acyl-coenzyme A oxidase 1
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UniprotKB/SwissProt ID: Q15067 (Q15067)
Gene Name:
ACOX1
Organism: Homo sapiens (Human)
Function: Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (PubMed:15060085, PubMed:17458872, PubMed:17603022, PubMed:32169171, PubMed:33234382, PubMed:7876265). Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) (PubMed:17458872, PubMed:17603022, PubMed:7876265) Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Peroxisome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q15067
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
199 |
VLAQLITKGK C YGLHAFIVPI |
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| 2 |
449 |
YDQVHSGKLV C GMVSYLNDLP |
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