Protein Name:
Lysine--tRNA ligase
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UniprotKB/SwissProt ID: Q15046 (Q15046)
Gene Name:
KARS1
Organism: Homo sapiens (Human)
Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:18029264, PubMed:18272479, PubMed:9278442). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:14975237, PubMed:19524539, PubMed:23159739, PubMed:5338216) (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Cytoplasm. Nucleus. Cell membrane. Secreted. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q15046
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
427 |
EETRKILDDI C VAKAVECPPP |
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| 2 |
434 |
DDICVAKAVE C PPPRTTARLL |
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| 3 |
496 |
FELFVMKKEI C NAYTELNDPM |
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| 4 |
534 |
DEAMFIDENF C TALEYGLPPT |
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