Protein Name:
ADP-ribosylation factor-like protein 6-interacting protein 1
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UniprotKB/SwissProt ID: Q15041 (Q15041)
Gene Name:
ARL6IP1
Organism: Homo sapiens (Human)
Function: Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endomembrane system. Endoplasmic reticulum membrane. Endoplasmic reticulum
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR052114
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ER_autophagy_membrane_reg |
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The S-nitrosylation sites of Q15041
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
109 |
TEQQQRFHEI C SNLVKTRRRA |
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