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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 116 kDa U5 small nuclear ribonucleoprotein component

UniprotKB/SwissProt ID: Q15029 (Q15029)

Gene Name: EFTUD2

Organism: Homo sapiens (Human)

Function: Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:25092792, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR041095 EFG_II
IPR035647 EFG_III/V
IPR000640 EFG_V-like
IPR004161 EFTu-like_2
IPR031950 EFTUD2_N
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_Su5_D2-typ_SF
IPR014721 Ribsml_uS5_D2-typ_fold_subgr
IPR005225 Small_GTP-bd
IPR044121 Snu114_GTP-bd
IPR000795 T_Tr_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR005517 Transl_elong_EFG/EF2_IV
IPR035655 U5-116kDa_C

The S-nitrosylation sites of Q15029

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 148 LHHGKTCFVD C LIEQTHPEIR   
2 166 EIRKRYDQDL C YTDILFTEQE   
3 468 DSDLGEAMSD C DPDGPLMCHT   
4 476 SDCDPDGPLM C HTTKMYSTDD   
5 525 TLEDEEDSQI C TVGRLWISVA   
6 663 IKVADPVVTF C ETVVETSSLK   
7 674 ETVVETSSLK C FAETPNKKNK   
8 780 FQWGTREGPL C DELIRNVKFK