Protein Name:
Condensin complex subunit 1
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UniprotKB/SwissProt ID: Q15021 (Q15021)
Gene Name:
NCAPD2
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q15021
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1000 |
DTEAELIRGI C EMELLDGKQT |
CCCCCEEECC C CCHHHHHHCC |
4.54% |
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| 2 |
1045 |
AAASLALGKF C MISATFCDSQ |
CCCCCEEECC C CCHHHHHHCC |
2.42% |
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| 3 |
1229 |
TERQQRDLAY C VSQLPLTERG |
CCCCCEEECC C CCHHHHHHCC |
1.65% |
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| 4 |
1249 |
GLRKMLDNFD C FGDKLSDESI |
CCCCCEEECC C CCHHHHHHCC |
3.43% |
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| 5 |
286 |
GEIVREIGQK C PQELSRDPSG |
CCCCCEEECC C CCHHHHHHCC |
3.02% |
22178444
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| 6 |
596 |
TGNMVTGQTV C KNKPNMSDPE |
CCCCCEEECC C CCHHHHHHCC |
4.58% |
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| 7 |
767 |
WERATEKVAC C PLERCSSVML |
CCCCCEEECC C CCHHHHHHCC |
2.88% |
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| 8 |
816 |
PQDYRLAQQV C HAIANISDRR |
CCCCCEEECC C CCHHHHHHCC |
1.24% |
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