Protein Name:
Spliceosome associated factor 3, U4/U6 recycling protein
|
UniprotKB/SwissProt ID: Q15020 (Q15020)
Gene Name:
SART3
Organism: Homo sapiens (Human)
Function: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity) Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus speckle. Cytoplasm
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q15020
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
182 |
LFEKAVKDYI C PNIWLEYGQY |
|
|
|
| 2 |
341 |
LIFERALVEN C LVPDLWIRYS |
|
|
|
| 3 |
472 |
ERFNESGDPS C VIMQNWARIE |
|
|
|
| 4 |
670 |
VEVAAGPAGK C AAVDVEPPSK |
|
|
|
| 5 |
749 |
FSNRGDFRGY C YVEFKEEKSA |
|
|
|
|
