Protein Name:
Pre-mRNA-splicing regulator WTAP
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UniprotKB/SwissProt ID: Q15007 (Q15007)
Gene Name:
WTAP
Organism: Homo sapiens (Human)
Function: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q15007
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
270 |
VEQSEATSKD C SRLTNGPSNG |
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| 2 |
90 |
LATKEQEMQE C TTQIQYLKQV |
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