Protein Name:
PCNA-associated factor
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UniprotKB/SwissProt ID: Q15004 (Q15004)
Gene Name:
PCLAF
Organism: Homo sapiens (Human)
Function: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm, perinuclear region
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q15004
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
54 |
ENKYAGGNPV C VRPTPKWQKG |
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| 2 |
99 |
SGLGKAKRKA C PLQPDHTNDE |
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