Protein Name:
Condensin complex subunit 2
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UniprotKB/SwissProt ID: Q15003 (Q15003)
Gene Name:
NCAPH
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR022816
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Condensin_barren_su2 |
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The S-nitrosylation sites of Q15003
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
239 |
NLNVSEADRK C EIDPMFQKTA |
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| 2 |
267 |
TAGVFLSTLH C QDYRSELLFP |
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| 3 |
296 |
GEPLELPELG C VEMTDLKAPL |
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| 4 |
309 |
MTDLKAPLQQ C AEDRQICPSL |
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| 5 |
397 |
HEEFRSWKEP C QVQSCQEEMI |
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| 6 |
402 |
SWKEPCQVQS C QEEMISLGDG |
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