Protein Name:
GTPase-activating protein and VPS9 domain-containing protein 1
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UniprotKB/SwissProt ID: Q14C86 (Q14C86)
Gene Name:
GAPVD1
Organism: Homo sapiens (Human)
Function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14C86
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1129 |
DAKKKLRLAL C SADSVAFPVL |
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| 2 |
1396 |
AYKTPRDKVQ C ILRMCSTIMN |
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| 3 |
275 |
FIGYLKQNTY C FPHSLRWIVS |
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| 4 |
293 |
IVSQMYKTLS C VDRLEVGEVR |
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| 5 |
568 |
KPDKTLRFSL C SDNLEGISEG |
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| 6 |
70 |
ITSAEASPAE C CQHAKILEDT |
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| 7 |
741 |
QEERLQELES C SGLGSTSDDT |
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| 8 |
789 |
PNKIEDLRSE C SSDFGGKDSV |
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