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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: E3 ubiquitin-protein ligase SHPRH

UniprotKB/SwissProt ID: Q149N8 (Q149N8)

Gene Name: SHPRH

Organism: Homo sapiens (Human)

Function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR052583 ATP-helicase/E3_Ub-Ligase
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C-like
IPR005818 Histone_H1/H5_H15
IPR027417 P-loop_NTPase
IPR048686 SHPRH_helical_1st
IPR048695 SHPRH_helical_2nd
IPR038718 SNF2-like_sf
IPR049730 SNF2/RAD54-like_C
IPR000330 SNF2_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR027370 Znf-RING_euk
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

The S-nitrosylation sites of Q149N8

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 520 LGKNYKEEDI C DKTKKQAVGS