Protein Name:
Zinc finger protein 638
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UniprotKB/SwissProt ID: Q14966 (Q14966)
Gene Name:
ZNF638
Organism: Homo sapiens (Human)
Function: Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus speckle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14966
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1156 |
PCEEEAEKAT C DSDFAVETLE |
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| 2 |
1198 |
IEQFTENAEE C ALNQQMFNSD |
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| 3 |
1654 |
TLDELIDQDD C ISHSEPKDVT |
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| 4 |
652 |
KNLEDDTLSE C KQVSDKAVSL |
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| 5 |
747 |
LTIKGKSVKI C VPGKKKAQNK |
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