Protein Name:
Chromodomain-helicase-DNA-binding protein 4
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UniprotKB/SwissProt ID: Q14839 (Q14839)
Gene Name:
CHD4
Organism: Homo sapiens (Human)
Function: ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14839
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1018 |
LLNVVMDLKK C CNHPYLFPVA |
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| 2 |
1019 |
LNVVMDLKKC C NHPYLFPVAA |
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| 3 |
1468 |
AYVSLFMRHL C EPGADGAETF |
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| 4 |
1594 |
KSTAPETAIE C TQAPAPASED |
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| 5 |
1827 |
ALNTRFAEVE C LAESHQHLSK |
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| 6 |
495 |
NGEWLCPRCT C PALKGKVQKI |
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