Protein Name:
Raftlin
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UniprotKB/SwissProt ID: Q14699 (Q14699)
Gene Name:
RFTN1
Organism: Homo sapiens (Human)
Function: Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm. Membrane raft. Endosome. Early endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14699
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
211 |
ENEKPGTGDV C SAPAGRNQSP |
CCCCCCHHCC C CCCCCCCHHH |
3.23% |
22178444
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