Protein Name:
Ribosomal RNA processing protein 1 homolog B
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UniprotKB/SwissProt ID: Q14684 (Q14684)
Gene Name:
RRP1B
Organism: Homo sapiens (Human)
Function: Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015) (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Nucleus, nucleoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14684
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
197 |
DQNLKFIDPF C KIAAKTKDHT |
CCCCCCHHHH H HHHHHHHCCC |
3.66% |
19483679
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| 2 |
286 |
GLSDERGRDD C GTFEDTGPLL |
CCCCCCHHHH H HHHHHHHCCC |
6.92% |
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| 3 |
386 |
LEKEKGSRVF C VEEEDSESSL |
CCCCCCHHHH H HHHHHHHCCC |
3.26% |
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| 4 |
628 |
QPQALGSSGT C SSLKKQKLRA |
CCCCCCHHHH H HHHHHHHCCC |
2.72% |
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